CHPY 301: INTRODUCTORY CHEMICAL PATHOLOGY Requests for and use of Chemical Pathology tests; collection and preservation of specimens for investigations; theory, use and limitations of reference values, selection of individuals for reference values; traditional and SI units of laboratory reports; sources of results variability; biological and non-biological factors, pre-analytical and post analytical factors; drug and drug-test interactions sources of laboratory errors and management; quality control and quality assurance programmes.
CHPY 402: CLINICAL BIOCHEMISTRY OF FLUID, ELECTROLYTE AND METABOLIC BALANCE
Water balance and imbalance, investigations of water imbalance; sodium balance, definition, causes, consequences and investigations of hyponatraemia, hypernatraemia; potassium balance, definitions, causes, consequences and investigations of hyperkalaemia and hypokalaeimia; acid base balance and blood gases, disorders of acid base balance; calcium and vitamin D metabolism, causes, consequences and investigations of hypercalcaemia and hypocalcaemia, metabolic bone diseases, rickets, osteomalacia and osteoporosis; blood glucose homeostasis, hormones involved in glucose homeostasis, causes and consequences of diabetes mellitus, causes and consequences of hyperglycaemia, investigations in hyperglycaemia, investigations in hypoglycaemia, plasma proteins and their abnormalities, paraproteinaemias, clinical significance of proteinurias; plasma lipids, free fatty acids, cholesterol, Triglycerides and phospholipids, Liporoproteins and dyslipoprteinaemias; risk factors for coronary artery disease and investigations; inherited metabolic disorders, including aminoaciduria, phenylktonuria, albinism, galactosaemia, fructose, lactose intolerance; nucleic acid metabolism, principles of DNA testing, clinical applications of DNA testing, plasma enzymes in clinical medicine; ALT, AST, ALP, ACP, CK, LD, GGT.
CHPY 403: CLINICAL BIOCHEMISTRY OF ORGAN FUNCTION
Renal function and renal function test, definition, causes, consequences and investigations of acute renal failure, chronic renal failure and nephritic syndrome; hepatic function and hepatic dysfunction and hepatic dysfunction tests, bilirubin metabolism and jaundice in adults and neonates, pancreatic function, dysfunction and investigations.
CHPY 404 CLINICAL BIOCHEMISTRY OF ENDOCRINE FUNCTION
Function and investigations of hypothalamus and anterior pituitary, dysfunction and investigations of hypothalamus and anterior pituitary; thyroid function and dysfunction, thyroid dysfunction and investigations; adrenocortical function and dysfunction, adrenocortical dysfunction and investigations, function and investigation of adrenal medulla; assessment of gonadal function in males and females, biochemical diagnosis and assessment of pregnancy, biochemical assessment of placental integrity and fetal well-being.
CHPY 405 CLINICAL NUTRITION
Major classes of food and their functions; carbohydrates and lipids, proteins, vitamins and minerals, iron nutrition, disorders and investigation of iron nutrition; daily energy and food requirements in health and disease, protein energy malnutrition, biochemical changes and effects; vitamin deficiency and consequences; fat soluble vitamins, water soluble vitamins, vitamin excess and consequences; over-nutrition; obesity, overweight, consequences, treatment and prevention; dietary fibre and disease, nutrition and cancer, assessment of nutritional status, parenteral and enteral nutrition.
CHPY 406 Uric acid, magnesium and other trace metals metabolism, definition, causes and investigation and consequences of gouts arthritis, clinical biochemist of cancer hyperuricaemia, Genetics Chemical Pathology, special tonigin chemical Pathology, Paediatrics chemical Pathology.
CHPY 407: PRACTICAL, TUTORIALS AND CASE DISCUSSION
Clinical samples for analysis, specimen collection procedures, specimen collection tubes, laboratory hazards and containment, specimen processing for analysis, sample transport, preservation and storage.
Urine analysis for:
PH, specific gravity, osmolality, protein and blood, including occult blood in urine and faeces, reducing substances, glucose and ketone bodies, bilirubin and urobilinogen; procedure, performance and interpretation of oral glucose tolerance test (OGTT), protein estimation in blood, urine and CSF; bilirubin estimation; serum enzymes, urinary 17-steroids; immunoassay of hormones and constituents; electrophoresis of proteins and enzymes.